The Hollywood actress, best known for starring opposite Burt Reynolds in 1979's Starting Over, passed away on Friday at her home in Lakeville, Connecticut.
The AP reports that Clayburgh has been suffering from chronic lymphocytic leukaemia for over 20 years.
During her career, the star was nominated for Academy Awards for Starting Over and 1978's An Unmarried Woman, for which she won the 'Best Actress' prize at the Cannes Film Festival.
Clayburgh has found television roles in recent years, including in Law & Order, Nip/Tuck, Ally McBeal and Dirty Sexy Money.
She is survived by her husband, screenwriter David Rabe, and three children, Lily, Michael and stepson Jason.
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